Transdermal Drug Delivery Group
Transdermal drug delivery is an optional mode of drug administration. It is a viable alternative if drug permeation across the skin is adequate. Formulation technologies can help in transdermal drug absorption, but skin irritation can often limit the use of these approaches. Appropriate cell culture models of the skin can help us to understand and predict these interactions; and, to facilitate development of new drugs as well as new drug formulations. In this regard, we have developed a human epidermis organotypic cell culture model that can be used for the analysis of transdermal drug delivery, high-throughput screening of chemical libraries, and development and testing of novel transdermal drug formulations.
Selected Publications:
- Organotypic cell cultures and two-photon imaging: tools for in vitro and in vivo assessment of percutaneous drug delivery and skin toxicity. Pappinen S, Pryazhnikov E, Khiroug L, Ericson MB, Yliperttula M, Urtti A. J Control Release. 2012 Jul 20;161(2):656-67.
- Comparison of rat epidermal keratinocyte organotypic culture (ROC) with intact human skin: lipid composition and thermal phase behavior of the stratum corneum. Pappinen S, Hermansson M, Kuntsche J, Somerharju P, Wertz P, Urtti A, Suhonen M. Biochim Biophys Acta. 2008 Apr;1778(4):824-34.
- Rat epidermal keratinocyte organotypic culture (ROC) compared to human cadaver skin: the effect of skin permeation enhancers. Pappinen S, Tikkinen S, Pasonen-Seppänen S, Murtomäki L, Suhonen M, Urtti A. Eur J Pharm Sci. 2007 Mar;30(3-4):240-50.
- Epidermal cell culture model with tight stratum corneum as a tool for dermal gene delivery studies. Paasonen L, Korhonen M, Yliperttula M, Urtti A. Int J Pharm. 2006 Jan 13;307(2):188-93.
- Epidermal cell culture model derived from rat keratinocytes with permeability characteristics comparable to human cadaver skin. Marjukka Suhonen T, Pasonen-Seppänen S, Kirjavainen M, Tammi M, Tammi R, Urtti A. Eur J Pharm Sci. 2003 Sep;20(1):107-13.
Arto Urtti, Ph.D, Professor
Professor Urtti has led the Centre for Drug Research (CDR) at the University of Helsinki since 2005. Professor Urtti’s has authored more than 220 peer-reviewed articles and 20 patents and patent applications.
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