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Transdermal drug delivery is an optional mode of drug administration. It is a viable alternative if drug permeation across the skin is adequate. Formulation technologies can help in transdermal drug absorption, but skin irritation can often limit the use of these approaches. Appropriate cell culture models of the skin can help us to understand and predict these interactions; and, to facilitate development of new drugs as well as new drug formulations. In this regard, we have developed a human epidermis organotypic cell culture model that can be used for the analysis of transdermal drug delivery, high-throughput screening of chemical libraries, and development and testing of novel transdermal drug 

formulations.