Transdermal Drug Delivery
Transdermal drug delivery is an optional mode of drug administration. It is a viable alternative if drug permeation across the skin is adequate. Formulation technologies can help in transdermal drug absorption, but skin irritation can often limit the use of these approaches. Appropriate cell culture models of the skin can help us to understand and predict these interactions; and, to facilitate development of new drugs as well as new drug formulations. In this regard, we have developed a human epidermis organotypic cell culture model that can be used for the analysis of transdermal drug delivery, high-throughput screening of chemical libraries, and development and testing of novel transdermal drug formulations.
Selected Publications:
- Organotypic cell cultures and two-photon imaging: tools for in vitro and in vivo assessment of percutaneous drug delivery and skin toxicity. Pappinen S, Pryazhnikov E, Khiroug L, Ericson MB, Yliperttula M, Urtti A. J Control Release. 2012 Jul 20;161(2):656-67.
- Comparison of rat epidermal keratinocyte organotypic culture (ROC) with intact human skin: lipid composition and thermal phase behavior of the stratum corneum. Pappinen S, Hermansson M, Kuntsche J, Somerharju P, Wertz P, Urtti A, Suhonen M. Biochim Biophys Acta. 2008 Apr;1778(4):824-34.
- Rat epidermal keratinocyte organotypic culture (ROC) compared to human cadaver skin: the effect of skin permeation enhancers. Pappinen S, Tikkinen S, Pasonen-Seppänen S, Murtomäki L, Suhonen M, Urtti A. Eur J Pharm Sci. 2007 Mar;30(3-4):240-50.
- Epidermal cell culture model with tight stratum corneum as a tool for dermal gene delivery studies. Paasonen L, Korhonen M, Yliperttula M, Urtti A. Int J Pharm. 2006 Jan 13;307(2):188-93.
- Epidermal cell culture model derived from rat keratinocytes with permeability characteristics comparable to human cadaver skin. Marjukka Suhonen T, Pasonen-Seppänen S, Kirjavainen M, Tammi M, Tammi R, Urtti A. Eur J Pharm Sci. 2003 Sep;20(1):107-13.
Arto Urtti, Ph.D, Professor
Arto Urtti received his Ph.D. in Pharmacy in 1986 (University of Kuopio, Finland). Professor Urtti has led the CDR at the University of Helsinki since 2005. Professor Urtti has authored more than 220 peer-reviewed articles and 20 patents and patent applications. Arto Urtti has received numerous scientific awards including: Innovation Award, American Association of Pharmaceutical Scientists Fellowship, Honorary Membership of the Finnish Pharmacists’ Association, the Albert Wuokko Prize, and the Millennium Distinction Award. He has served as editor-in-chief of the European Journal of Pharmaceutical Sciences and as editorial board member for many other international journals. Professor Urtti’s main research fields include drug delivery (controlled release, computational and cell-based methods for ADME research) and nanotechnology (biomaterial structures for drug and gene targeting and for 3-d cell cultures).
Login to post comments
